Product Title: VIP - Vasoactive Intestinal Peptide X 5mg
URL handle: vip-vasoactive-intestinal-peptide-5mg-biolongevity-labs
SKU: VIP-5MG
Brand: Biolongevity Labs
Current URL: https://fmihealth.com/products/vip-vasoactive-intestinal-peptide-5mg-biolongevity-labs
Shopify URL: https://admin.shopify.com/store/thebestnutrients/products/8881726259355
Meta Title: VIP - Vasoactive Intestinal Peptide X 5mg
Meta Description: Description--VIP is a 28‑amino acid regulatory hormone peptide that controls smooth muscle relaxation and secretion processes across multiple biological systems. It plays a central role in cellular signaling, vascular function, and secretory regulation, making it a valuable research tool for investigating therapeutic p
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<p>Description--VIP is a 28‑amino acid regulatory hormone peptide that controls smooth muscle relaxation and secretion processes across multiple biological systems. It plays a central role in cellular signaling, vascular function, and secretory regulation, making it a valuable research tool for investigating therapeutic pathways in controlled laboratory settings.</p> <p> </p> <p><strong>Mechanistic Claims</strong></p> <ul> <li> <strong>Smooth Muscle Regulation:</strong> Mediates relaxation of vascular, gastrointestinal, and respiratory smooth muscle.</li> <li> <strong>Secretory Control:</strong> Influences secretion in endocrine and exocrine tissues.</li> <li> <strong>Cellular Signaling:</strong> Acts through G‑protein coupled receptors to regulate cyclic AMP pathways.</li> <li> <strong>Vascular Function:</strong> Supports vasodilation and blood flow regulation.</li> <li> <strong>Neuroprotective &amp; Immunomodulatory Potential:</strong> Explored for roles in inflammation, immune balance, and neuronal signaling.</li> </ul> <p> </p> <p><strong>Research Applications</strong></p> <ul> <li>Vascular biology and vasodilation studies</li> <li>Smooth muscle physiology investigations</li> <li>Secretory pathway and endocrine/exocrine regulation models</li> <li>Neuroprotection and immunomodulation research</li> <li>Exploratory therapeutic studies in inflammation and respiratory health</li> </ul> <p> </p> <p><strong>VIP Research Insights</strong></p> <ul> <li>28‑amino acid peptide hormone with broad systemic regulatory roles.</li> <li>Studied for effects on smooth muscle, vascular tone, and secretory activity.</li> <li>Research highlights potential in immune modulation, neuroprotection, and inflammation control.</li> <li>Supplied in pharmaceutical‑grade, lyophilized form to ensure purity and stability.</li> <li>Recommended handling: reconstitute with bacteriostatic water immediately before use; aliquot single‑use portions; store at ≤ –20 °C to avoid repeated freeze–thaw cycles.</li> </ul> <p><!--EndFragment --><br></p> <p><strong>VIP Research</strong></p> <p>VIP research spans multiple biological systems, offering laboratories diverse opportunities to study this 28-amino acid peptide’s regulatory mechanisms.</p> <p> </p> <p><em><strong>Cardiovascular Research</strong></em></p> <p>VIP acts as a potent vasodilator by binding to VPAC receptors and increasing nitric oxide production. Laboratory studies show VIP influences coronary blood flow and heart rate regulation through its presence in cardiac nerve fibers[1].</p> <p> </p> <p><strong><em>Digestive System Studies</em></strong></p> <p>Research demonstrates VIP’s role in gut motility regulation through smooth muscle relaxation in the esophageal sphincter and stomach. The peptide stimulates pancreatic secretion of water and electrolytes while inhibiting gastric acid production[2].</p> <p> </p> <p><strong><em>Immune System Investigations</em></strong></p> <p>VIP exhibits anti-inflammatory properties by binding to VPAC1 and VPAC2 receptors on immune cells. Studies show the peptide inhibits T-cell proliferation and suppresses inflammatory cytokine production from macrophages and microglia[3].</p> <p> </p> <p><strong><em>Neurological Research</em></strong></p> <p>Laboratory investigations reveal VIP’s neuroprotective effects on dopaminergic neurons through microglial modulation. The peptide plays a central role in circadian rhythm regulation via VPAC2 receptor activation in the suprachiasmatic nucleus[4].</p> <p> </p> <p><strong><em>Receptor Mechanisms</em></strong></p> <p>VIP research focuses on VPAC1 and VPAC2 receptor interactions that trigger adenylate cyclase activation and cAMP elevation[5]. These signaling cascades activate protein kinase A pathways across different cell types[6].</p> <p> </p> <p><strong>References</strong></p> <ol> <li>R. Henning, “Vasoactive intestinal peptide: cardiovascular effects,” Oxford University Press (OUP), Jan. 2001. doi: 10.1016/s0008-6363(00)00229-7. <a href="https://doi.org/10.1016/s0008-6363(00)00229-7" rel="noopener" target="_blank">https://doi.org/10.1016/s0008-6363(00)00229-7</a> </li> <li>M. Iwasaki, Y. Akiba, and J. D. Kaunitz, “Recent advances in vasoactive intestinal peptide physiology and pathophysiology: focus on the gastrointestinal system,” F1000 Research Ltd, Sep. 2019. doi: 10.12688/f1000research.18039.1. <a href="https://doi.org/10.12688/f1000research.18039.1" rel="noopener" target="_blank">https://doi.org/10.12688/f1000research.18039.1</a> </li> <li>C. Martínez <em>et al.</em>, “A Clinical Approach for the Use of VIP Axis in Inflammatory and Autoimmune Diseases,” MDPI AG, Dec. 2019. doi: 10.3390/ijms21010065. https://doi.org/10.3390/ijms21010065</li> <li>J. Fahrenkrug, “Transmitter Role of Vasoactive Intestinal Peptide,” Wiley, Jun. 1993. doi: 10.1111/j.1600-0773.1993.tb01344.x. <a href="https://doi.org/10.1111/j.1600-0773.1993.tb01344.x" rel="noopener" target="_blank">https://doi.org/10.1111/j.1600-0773.1993.tb01344.x</a> </li> <li>I. Langer, “Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies,” Frontiers Media SA, 2012. doi: 10.3389/fendo.2012.00129. <a href="https://doi.org/10.3389/fendo.2012.00129" rel="noopener" target="_blank">https://doi.org/10.3389/fendo.2012.00129</a> </li> <li>I. Kato <em>et al.</em>, “Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo.,”<span> </span><em>Journal of Biological Chemistry</em>, vol. 269 33, pp. 21223–8, 1994.</li> </ol> <p><br><br>Label--<strong>Peptide Information</strong></p> <table class="bg-bg-100 min-w-full border-separate border-spacing-0 text-sm leading-[1.88888] whitespace-normal" style="width: 99.9363%;"> <thead class="border-b-border-100/50 border-b-[0.5px] text-left"> <tr class="[tbody&gt;&amp;]:odd:bg-bg-500/10"> <th class="text-text-000 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 20.4434%;">Property</th> <th class="text-text-000 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 79.2367%;">Value</th> </tr> </thead> <tbody> <tr class="[tbody&gt;&amp;]:odd:bg-bg-500/10"> <td class="border-t-border-100/50 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] border-t-[0.5px] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 20.4434%;">Peptide Sequence</td> <td class="border-t-border-100/50 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] border-t-[0.5px] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 79.2367%;">His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2</td> </tr> <tr class="[tbody&gt;&amp;]:odd:bg-bg-500/10"> <td class="border-t-border-100/50 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] border-t-[0.5px] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 20.4434%;">Molecular Formula</td> <td class="border-t-border-100/50 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] border-t-[0.5px] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 79.2367%;">C147H238N44O42S</td> </tr> <tr class="[tbody&gt;&amp;]:odd:bg-bg-500/10"> <td class="border-t-border-100/50 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] border-t-[0.5px] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 20.4434%;">Molecular Weight</td> <td class="border-t-border-100/50 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] border-t-[0.5px] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 79.2367%;">3325.8 g/mol</td> </tr> <tr class="[tbody&gt;&amp;]:odd:bg-bg-500/10"> <td class="border-t-border-100/50 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] border-t-[0.5px] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 20.4434%;">CAS Number</td> <td class="border-t-border-100/50 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] border-t-[0.5px] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 79.2367%;">40077-57-4</td> </tr> <tr class="[tbody&gt;&amp;]:odd:bg-bg-500/10"> <td class="border-t-border-100/50 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] border-t-[0.5px] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 20.4434%;">PubChem CID</td> <td class="border-t-border-100/50 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] border-t-[0.5px] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 79.2367%;">53314964</td> </tr> <tr class="[tbody&gt;&amp;]:odd:bg-bg-500/10"> <td class="border-t-border-100/50 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] border-t-[0.5px] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 20.4434%;">Synonyms</td> <td class="border-t-border-100/50 [&amp;:not(:first-child)]:-x-[hsla(var(--border-100) / 0.5)] border-t-[0.5px] px-2 [&amp;:not(:first-child)]:border-l-[0.5px]" style="width: 79.2367%;">VIP, Aviptadil, Vasoactive Intestinal Polypeptide, Vasoactive Intestinal Peptide</td> </tr> </tbody> </table> <style type="text/css"> td {border: 1px solid #cccccc;} br {mso-data-placement: same-cell;} .bold {font-weight: bold;} </style> <p><br>Dosage--<strong>This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY.</strong><span> This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only.  This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug.</span></p>

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