The Intestinal Permeability Assessment (IPA - G) is a urine-based test that measures the percentage recovery of lactulose and mannitol following oral ingestion. The test assesses urinary recovery values and the lactulose-to-mannitol ratio using enzymatic methodology, providing quantitative markers related to intestinal permeability.
This test may be clinically useful when practitioners are exploring how substances pass through the intestinal lining. Comparing the recovery of two differently sized sugars offers insight into permeability patterns that may relate to digestive symptoms, food reactions or inflammatory presentations.
Practitioners typically interpret IPA results alongside clinical history, dietary intake, medication use and other relevant laboratory findings. Results are considered in context, including renal function and timing of sample collection, when reviewing findings with clients.
