      Product Title: Epithalon X 20mg

      URL handle: epithalon-20mg-biolongevity-labs

      SKU: EPIT-20MG

      Brand: Biolongevity Labs

      Current URL: https://fmihealth.com/products/epithalon-20mg-biolongevity-labs

      Meta Title: Epithalon X 20mg

      Meta Description: Description--Epithalon (also known as Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural pineal peptide epithalamin. It has been studied extensively in longevity and aging research for its role as a bioregulator of cellular processes.   Mechanistic Claims Telomerase Activation: Stimulates 

      Health Conditions: Longevity | Anti-aging | Cellular Regeneration



      Description HTML:

      <p>Description--Epithalon (also known as Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural pineal peptide epithalamin. It has been studied extensively in longevity and aging research for its role as a bioregulator of cellular processes.</p>
<p> </p>
<p><strong>Mechanistic Claims</strong></p>
<ul>
<li>
<strong>Telomerase Activation:</strong> Stimulates telomerase activity, enabling elongation and maintenance of telomeres, the protective caps at the ends of chromosomes.</li>
<li>
<strong>Telomere Length Regulation:</strong> Shown to preserve or extend telomere length in preclinical models, potentially delaying cellular senescence.</li>
<li>
<strong>Pineal Gland Modulation:</strong> Influences melatonin secretion and circadian rhythm regulation, contributing to systemic anti-aging effects.</li>
<li>
<strong>Antioxidant &amp; Anti-Aging Pathways:</strong> Reduces oxidative stress markers and supports mitochondrial function.</li>
<li>
<strong>Gene Expression Regulation:</strong> Modulates expression of genes associated with stress resistance, apoptosis, and DNA repair.</li>
</ul>
<p> </p>
<p><strong>Research Applications</strong></p>
<ul>
<li>Longevity and anti-aging studies</li>
<li>Telomere biology and telomerase modulation</li>
<li>Circadian rhythm and pineal gland function</li>
<li>Oxidative stress and mitochondrial resilience</li>
<li>DNA repair and genomic stability investigations</li>
</ul>
<p><!--EndFragment --><br></p>
<p><strong>Epithalon Research Insights</strong></p>
<p class="whitespace-pre-wrap break-words">Epithalon (also spelled Epitalon) is a synthetic tetrapeptide consisting of four amino acids: Alanine-Glutamic Acid-Aspartic Acid-Glycine (Ala-Glu-Asp-Gly). It was developed and primarily studied in Russia by researchers at the St. Petersburg Institute of Bioregulation and Gerontology.</p>
<p class="whitespace-pre-wrap break-words">The peptide was designed to mimic epithalamin, a natural extract from the pineal gland. Its key characteristics include:</p>
<ul class="[&amp;:not(:last-child)_ul]:pb-1 [&amp;:not(:last-child)_ol]:pb-1 list-disc space-y-1.5 pl-7">
<li class="whitespace-normal break-words">
<p>Purported anti-aging properties</p>
</li>
<li class="whitespace-normal break-words">
<p>Potential to stimulate production of telomerase (an enzyme that can help maintain telomere length)</p>
</li>
<li class="whitespace-normal break-words">
<p>Possible regulation of melatonin production and circadian rhythms</p>
</li>
<li class="whitespace-normal break-words">
<p>Studies suggesting effects on immune function</p>
</li>
</ul>
<p class="whitespace-pre-wrap break-words">Most research on Epithalon has been conducted in Russia, with some animal studies showing potential lifespan extension effects.</p>
<p class="whitespace-pre-wrap break-words"> </p>
<p class="whitespace-pre-wrap break-words"><strong><em>Telomere Dynamics and Telomerase Activity</em></strong></p>
<p>Epithalon has been shown to activate telomerase in various cell types. Studies indicate that Epithalon can induce the expression of the telomerase catalytic subunit and enhance its enzymatic activity, leading to telomere elongation in human somatic <span class="whitespace-nowrap">cells. This activation of telomerase suggests a potential mechanism by which Epithalon may prolong the lifespan of cells and possibly the organism as a whole<sup>1</sup>.</span></p>
<p><span class="whitespace-nowrap">Research demonstrates that Epithalon can significantly retard cellular senescence by reducing telomere shortening and promoting telomere elongation. In aging models, Epithalon-treated cells showed increased telomere length and extended proliferative potential, effectively overcoming the Hayflick limit, which is the typical division limit of somatic cells<sup>2</sup>.</span></p>
<p> </p>
<p><strong><em>Longevity and Anti-Aging Effects</em></strong></p>
<p>Epithalon has been shown to increase the lifespan of various organisms. In mice, it increased the lifespan of the last 10% of survivors by 13.3% and the maximum lifespan by <span class="whitespace-nowrap">12.3%<sup>3</sup>. In Drosophila melanogaster, it extended lifespan by 11-16% at very low concentrations<sup>4</sup>.</span></p>
<p><span class="whitespace-nowrap">Epithalon can retard cellular senescence by reducing telomere shortening and increasing telomerase activity, which helps prolong cell lifespan<sup>5</sup>. It decreases the frequency of chromosome aberrations, indicating an antimutagenic effect that may contribute to its geroprotective properties<sup>6</sup>.</span></p>
<p><span class="whitespace-nowrap">In oocytes, Epithalon reduces reactive oxygen species and improves mitochondrial function, which may delay aging processes<sup>7</sup>. In older primates, Epithalon has been shown to restore age-related hormonal imbalances, such as increasing melatonin levels and improving glucose metabolism<sup>8</sup>.</span></p>
<p><span class="whitespace-nowrap">Epithalon influences gene expression related to aging and stress responses, potentially through interactions with DNA<sup>9</sup>.</span></p>
<p> </p>
<p><strong><em>Antioxidant Properties</em></strong></p>
<p>Epithalon has been shown to reduce intracellular ROS levels, which are harmful byproducts of cellular metabolism that can lead to oxidative stress and cellular damage<sup>10</sup>. This reduction in ROS is associated with improved mitochondrial function and decreased apoptosis in aging oocytes, suggesting a protective role against cellular <span class="whitespace-nowrap">aging<sup>7</sup>.</span></p>
<p><span class="whitespace-nowrap">Studies indicate that Epithalon’s antioxidant properties can surpass those of melatonin in certain contexts. While both compounds are produced by the pineal gland, Epithalon not only acts as a direct antioxidant but also stimulates the production of antioxidant enzymes, providing a broader protective effect<sup>10</sup>.</span></p>
<p> </p>
<p><strong><em>Tumor Inhibition</em></strong></p>
<p>Epithalon has demonstrated significant inhibitory effects on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Studies show that Epithalon treatment reduces both the cumulative number and size of tumors, and decreases the number of mice with multiple <span class="whitespace-nowrap">tumors<sup>11</sup>.</span></p>
<p><span class="whitespace-nowrap">In rat models, Epithalon has been shown to inhibit colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH). The peptide reduces the number and size of colon tumors, particularly when administered throughout the carcinogenesis process<sup>12</sup>.</span></p>
<p><span class="whitespace-nowrap">The antitumor effects of Epithalon are partly attributed to its ability to downregulate oncogene expression, such as HER-2/neu in mammary tumors<sup>11</sup>.</span></p>
<p> </p>
<p><strong>References</strong></p>
<ol>
<li>
<p>Khavinson, V., Bondarev, I., &amp; Butyugov, A. (2003). Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. <em>Bulletin of Experimental Biology and Medicine</em>, 135, 590-592. <a rel="noopener" href="https://doi.org/10.1023/A:1025493705728" target="_blank">https://doi.org/10.1023/A:1025493705728</a>.</p>
</li>
<li>
<p>Shi-Liang, T. (2007). Retarding the cellular senescence by Epithalon and changes of telomere length and telomerase activity in the retarding process. <em>Journal of Chongqing College of Education</em>.</p>
</li>
<li>
<p>Anisimov, V., Khavinson, V., Popovich, I., Zabezhinski, M., Alimova, I., Rosenfeld, S., Zavarzina, N., Semenchenko, A., &amp; Yashin, A. (2004). Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. <em>Biogerontology</em>, 4, 193-202. <a rel="noopener" href="https://doi.org/10.1023/A:1025114230714" target="_blank">https://doi.org/10.1023/A:1025114230714</a>.</p>
</li>
<li>
<p>Khavinson, V., Izmaylov, D., Obukhova, L., &amp; Malinin, V. (2000). Effect of epitalon on the lifespan increase in Drosophila melanogaster . <em>Mechanisms of Ageing and Development</em>, 120, 141-149. <a rel="noopener" href="https://doi.org/10.1016/S0047-6374(00)00217-7" target="_blank">https://doi.org/10.1016/S0047-6374(00)00217-7</a>.</p>
</li>
<li>
<p>Khavinson, V., Bondarev, I., Butyugov, A., &amp; Smirnova, T. (2004). Peptide Promotes Overcoming of the Division Limit in Human Somatic Cell. <em>Bulletin of Experimental Biology and Medicine</em>, 137, 503-506. <a rel="noopener" href="https://doi.org/10.1023/B:BEBM.0000038164.49947.8c" target="_blank">https://doi.org/10.1023/B:BEBM.0000038164.49947.8c</a>.</p>
</li>
<li>
<p>Rosenfeld, S., Togo, E., Mikheev, V., Popovich, I., Zabezhinskii, M., Khavinson, V., &amp; Anisimov, V. (2002). Effect of Epithalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated Mice. <em>Bulletin of Experimental Biology and Medicine</em>, 133, 274-276. <a rel="noopener" href="https://doi.org/10.1023/A:1015899003974" target="_blank">https://doi.org/10.1023/A:1015899003974</a>.</p>
</li>
<li>
<p>Yue, X., Liu, S., Guo, J., Meng, T., Zhang, X., Li, H., Song, C., Wang, Z., Schatten, H., Sun, Q., &amp; Guo, X. (2022). Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro. <em>Aging (Albany NY)</em>, 14, 3191 – 3202. <a rel="noopener" href="https://doi.org/10.18632/aging.204007" target="_blank">https://doi.org/10.18632/aging.204007</a>.</p>
</li>
<li>
<p>Goncharova, N., Vengerin, A., Khavinson, V., &amp; Lapin, B. (2005). Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas. <em>Experimental Gerontology</em>, 40, 51-57. <a rel="noopener" href="https://doi.org/10.1016/j.exger.2004.10.004" target="_blank">https://doi.org/10.1016/j.exger.2004.10.004</a>.</p>
</li>
<li>
<p>Khavinson, V., &amp; Malinin, V. (2005). Gerontological Aspects of Genome Peptide Regulation. . <a rel="noopener" href="https://doi.org/10.1159/isbn.978-3-318-01193-7" target="_blank">https://doi.org/10.1159/isbn.978-3-318-01193-7</a>.</p>
</li>
<li>
<p>Kozina, L., Arutjunyan, A., &amp; Khavinson, V. (2007). Antioxidant properties of geroprotective peptides of the pineal gland.. <em>Archives of gerontology and geriatrics</em>, 44 Suppl 1, 213-6 . <a rel="noopener" href="https://doi.org/10.1016/J.ARCHGER.2007.01.029" target="_blank">https://doi.org/10.1016/J.ARCHGER.2007.01.029</a>.</p>
</li>
<li>
<p>Anisimov, V., Khavinsov, V., Alimova, I., Provintsiali, M., Manchini, R., &amp; Francheski, K. (2002). Epithalon Inhibits Tumor Growth and Expression of HER-2/neu Oncogene in Breast Tumors in Transgenic Mice Characterized by Accelerated Aging. <em>Bulletin of Experimental Biology and Medicine</em>, 133, 167-170. <a rel="noopener" href="https://doi.org/10.1023/A:1015555023692" target="_blank">https://doi.org/10.1023/A:1015555023692</a>.</p>
</li>
<li>
<p>Anisimov, V., Khavinson, V., Popovich, I., &amp; Zabezhinski, M. (2002). Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.. <em>Cancer letters</em>, 183 1, 1-8 . <a rel="noopener" href="https://doi.org/10.1016/S0304-3835(02)00090-3" target="_blank">https://doi.org/10.1016/S0304-3835(02)00090-3</a>.</p>
</li>
</ol>
<p><br>Label--<strong>Peptide Information</strong></p>
<table style="width: 99.9363%;">
<thead>
<tr>
<th style="width: 29.4596%;">
<p>Property</p>
</th>
<th style="width: 70.2205%;">
<p>Value</p>
</th>
</tr>
</thead>
<tbody>
<tr>
<td style="width: 29.4596%;">
<p>Peptide Sequence</p>
</td>
<td style="width: 70.2205%;">
<p>Ala-Glu-Asp-Gly</p>
</td>
</tr>
<tr>
<td style="width: 29.4596%;">
<p>Molecular Formula</p>
</td>
<td style="width: 70.2205%;">
<p>C14H22N4O9</p>
</td>
</tr>
<tr>
<td style="width: 29.4596%;">
<p>Molecular Weight</p>
</td>
<td style="width: 70.2205%;">
<p>390.35 g/mol</p>
</td>
</tr>
<tr>
<td style="width: 29.4596%;">
<p>CAS Number</p>
</td>
<td style="width: 70.2205%;">
<p>307297-39-8</p>
</td>
</tr>
<tr>
<td style="width: 29.4596%;">
<p>PubChem CID</p>
</td>
<td style="width: 70.2205%;">
<p>219042</p>
</td>
</tr>
<tr>
<td style="width: 29.4596%;">
<p>Synonyms</p>
</td>
<td style="width: 70.2205%;">
<p>307297-39-8, Glycine, L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-, Ala-Glu-Asp-Gly</p>
</td>
</tr>
</tbody>
</table>
<p> </p>
<p style="text-align: center;"><strong>Epithalon Peptide Structure</strong></p>
<p><strong><img src="https://pubchem.ncbi.nlm.nih.gov/image/imgsrv.fcgi?cid=219042&amp;t=l" alt="Epitalon.png" style="display: block; margin-left: auto; margin-right: auto;"></strong></p>
<p><span>Source: </span><a href="https://pubchem.ncbi.nlm.nih.gov/compound/219042#section=2D-Structure" rel="noopener" target="_blank">PubChem</a></p>
<p>Dosage--<strong>This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY.</strong><span> This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.</span></p>
    

      
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Epithalon X 20mg

Biolongevity Labs

Longevity | Anti-aging | Cellular Regeneration

Rs. 11,421

Unit price: per

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Made in USA

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Epithalon X 20mg

Name: Epithalon X 20mg
Brand: Biolongevity Labs
SKU: EPIT-20MG
Price: 11421.0 INR
Availability: InStock

Longevity | Anti-aging | Cellular Regeneration

Biolongevity Labs

Rs. 11,421

Unit price: per

No Reviews

Rs. 11,421

Unit price: per

Price includes all duties and taxes

SKU: EPIT-20MG FMI's Choice

About the Product

Epithalon Tetrapeptide (20 mg) Research Compound: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) for preclinical studies on cellular longevity, telomere biology, anti-aging pathways, and tissue regeneration mechanisms.
Telomerase & Cellular Bioregulation: Investigated for modulation of telomerase activity, telomere maintenance, and influence on cellular pathways associated with aging, regeneration, and chromosomal stability.
Longevity & Cellular Research Applications: Supports research on telomerase activity, telomere preservation, cellular regeneration, chromosomal stability, anti-aging pathway modulation, and bioregulation mechanisms.
Pure Research-Grade Tetrapeptide: Optimized synthetic peptide designed for stability, reproducibility, and precise preclinical investigation of longevity and anti-aging pathways.
Intended Use: For qualified researchers conducting controlled laboratory studies. Not for human or veterinary use.

Epithalon (also known as Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the natural pineal peptide epithalamin. It has been studied extensively in longevity and aging research for its role as a bioregulator of cellular processes.

Mechanistic Claims

Telomerase Activation: Stimulates telomerase activity, enabling elongation and maintenance of telomeres, the protective caps at the ends of chromosomes.
Telomere Length Regulation: Shown to preserve or extend telomere length in preclinical models, potentially delaying cellular senescence.
Pineal Gland Modulation: Influences melatonin secretion and circadian rhythm regulation, contributing to systemic anti-aging effects.
Antioxidant & Anti-Aging Pathways: Reduces oxidative stress markers and supports mitochondrial function.
Gene Expression Regulation: Modulates expression of genes associated with stress resistance, apoptosis, and DNA repair.

Research Applications

Longevity and anti-aging studies
Telomere biology and telomerase modulation
Circadian rhythm and pineal gland function
Oxidative stress and mitochondrial resilience
DNA repair and genomic stability investigations

Epithalon Research Insights

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide consisting of four amino acids: Alanine-Glutamic Acid-Aspartic Acid-Glycine (Ala-Glu-Asp-Gly). It was developed and primarily studied in Russia by researchers at the St. Petersburg Institute of Bioregulation and Gerontology.

The peptide was designed to mimic epithalamin, a natural extract from the pineal gland. Its key characteristics include:

Purported anti-aging properties
Potential to stimulate production of telomerase (an enzyme that can help maintain telomere length)
Possible regulation of melatonin production and circadian rhythms
Studies suggesting effects on immune function

Most research on Epithalon has been conducted in Russia, with some animal studies showing potential lifespan extension effects.

Telomere Dynamics and Telomerase Activity

Epithalon has been shown to activate telomerase in various cell types. Studies indicate that Epithalon can induce the expression of the telomerase catalytic subunit and enhance its enzymatic activity, leading to telomere elongation in human somatic cells. This activation of telomerase suggests a potential mechanism by which Epithalon may prolong the lifespan of cells and possibly the organism as a whole¹.

Research demonstrates that Epithalon can significantly retard cellular senescence by reducing telomere shortening and promoting telomere elongation. In aging models, Epithalon-treated cells showed increased telomere length and extended proliferative potential, effectively overcoming the Hayflick limit, which is the typical division limit of somatic cells².

Longevity and Anti-Aging Effects

Epithalon has been shown to increase the lifespan of various organisms. In mice, it increased the lifespan of the last 10% of survivors by 13.3% and the maximum lifespan by 12.3%³. In Drosophila melanogaster, it extended lifespan by 11-16% at very low concentrations⁴.

Epithalon can retard cellular senescence by reducing telomere shortening and increasing telomerase activity, which helps prolong cell lifespan⁵. It decreases the frequency of chromosome aberrations, indicating an antimutagenic effect that may contribute to its geroprotective properties⁶.

In oocytes, Epithalon reduces reactive oxygen species and improves mitochondrial function, which may delay aging processes⁷. In older primates, Epithalon has been shown to restore age-related hormonal imbalances, such as increasing melatonin levels and improving glucose metabolism⁸.

Epithalon influences gene expression related to aging and stress responses, potentially through interactions with DNA⁹.

Antioxidant Properties

Epithalon has been shown to reduce intracellular ROS levels, which are harmful byproducts of cellular metabolism that can lead to oxidative stress and cellular damage¹⁰. This reduction in ROS is associated with improved mitochondrial function and decreased apoptosis in aging oocytes, suggesting a protective role against cellular aging⁷.

Studies indicate that Epithalon’s antioxidant properties can surpass those of melatonin in certain contexts. While both compounds are produced by the pineal gland, Epithalon not only acts as a direct antioxidant but also stimulates the production of antioxidant enzymes, providing a broader protective effect¹⁰.

Tumor Inhibition

Epithalon has demonstrated significant inhibitory effects on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Studies show that Epithalon treatment reduces both the cumulative number and size of tumors, and decreases the number of mice with multiple tumors¹¹.

In rat models, Epithalon has been shown to inhibit colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH). The peptide reduces the number and size of colon tumors, particularly when administered throughout the carcinogenesis process¹².

The antitumor effects of Epithalon are partly attributed to its ability to downregulate oncogene expression, such as HER-2/neu in mammary tumors¹¹.

References

Khavinson, V., Bondarev, I., & Butyugov, A. (2003). Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bulletin of Experimental Biology and Medicine, 135, 590-592. https://doi.org/10.1023/A:1025493705728.
Shi-Liang, T. (2007). Retarding the cellular senescence by Epithalon and changes of telomere length and telomerase activity in the retarding process. Journal of Chongqing College of Education.
Anisimov, V., Khavinson, V., Popovich, I., Zabezhinski, M., Alimova, I., Rosenfeld, S., Zavarzina, N., Semenchenko, A., & Yashin, A. (2004). Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology, 4, 193-202. https://doi.org/10.1023/A:1025114230714.
Khavinson, V., Izmaylov, D., Obukhova, L., & Malinin, V. (2000). Effect of epitalon on the lifespan increase in Drosophila melanogaster . Mechanisms of Ageing and Development, 120, 141-149. https://doi.org/10.1016/S0047-6374(00)00217-7.
Khavinson, V., Bondarev, I., Butyugov, A., & Smirnova, T. (2004). Peptide Promotes Overcoming of the Division Limit in Human Somatic Cell. Bulletin of Experimental Biology and Medicine, 137, 503-506. https://doi.org/10.1023/B:BEBM.0000038164.49947.8c.
Rosenfeld, S., Togo, E., Mikheev, V., Popovich, I., Zabezhinskii, M., Khavinson, V., & Anisimov, V. (2002). Effect of Epithalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated Mice. Bulletin of Experimental Biology and Medicine, 133, 274-276. https://doi.org/10.1023/A:1015899003974.
Yue, X., Liu, S., Guo, J., Meng, T., Zhang, X., Li, H., Song, C., Wang, Z., Schatten, H., Sun, Q., & Guo, X. (2022). Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro. Aging (Albany NY), 14, 3191 – 3202. https://doi.org/10.18632/aging.204007.
Goncharova, N., Vengerin, A., Khavinson, V., & Lapin, B. (2005). Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas. Experimental Gerontology, 40, 51-57. https://doi.org/10.1016/j.exger.2004.10.004.
Khavinson, V., & Malinin, V. (2005). Gerontological Aspects of Genome Peptide Regulation. . https://doi.org/10.1159/isbn.978-3-318-01193-7.
Kozina, L., Arutjunyan, A., & Khavinson, V. (2007). Antioxidant properties of geroprotective peptides of the pineal gland.. Archives of gerontology and geriatrics, 44 Suppl 1, 213-6 . https://doi.org/10.1016/J.ARCHGER.2007.01.029.
Anisimov, V., Khavinsov, V., Alimova, I., Provintsiali, M., Manchini, R., & Francheski, K. (2002). Epithalon Inhibits Tumor Growth and Expression of HER-2/neu Oncogene in Breast Tumors in Transgenic Mice Characterized by Accelerated Aging. Bulletin of Experimental Biology and Medicine, 133, 167-170. https://doi.org/10.1023/A:1015555023692.
Anisimov, V., Khavinson, V., Popovich, I., & Zabezhinski, M. (2002). Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.. Cancer letters, 183 1, 1-8 . https://doi.org/10.1016/S0304-3835(02)00090-3.

Label--Peptide Information

Property	Value
Peptide Sequence	Ala-Glu-Asp-Gly
Molecular Formula	C14H22N4O9
Molecular Weight	390.35 g/mol
CAS Number	307297-39-8
PubChem CID	219042
Synonyms	307297-39-8, Glycine, L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-, Ala-Glu-Asp-Gly

Epithalon Peptide Structure

Source: PubChem

Dosage--This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation allows the use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website is for educational purposes only. This product should only be handled by licensed, qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused or mislabeled as a drug, food or cosmetic.

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Made in USA

Authorised distributor

1 - 5 days delivery

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Disclaimer

: Not a diet substitute. Seek Medical guidance if unsure before use.

Product Information Sheet

Mechanistic Claims

Telomerase Activation: Stimulates telomerase activity, enabling elongation and maintenance of telomeres, the protective caps at the ends of chromosomes.
Telomere Length Regulation: Shown to preserve or extend telomere length in preclinical models, potentially delaying cellular senescence.
Pineal Gland Modulation: Influences melatonin secretion and circadian rhythm regulation, contributing to systemic anti-aging effects.
Antioxidant & Anti-Aging Pathways: Reduces oxidative stress markers and supports mitochondrial function.
Gene Expression Regulation: Modulates expression of genes associated with stress resistance, apoptosis, and DNA repair.

Research Applications

Longevity and anti-aging studies
Telomere biology and telomerase modulation
Circadian rhythm and pineal gland function
Oxidative stress and mitochondrial resilience
DNA repair and genomic stability investigations

Epithalon Research Insights

The peptide was designed to mimic epithalamin, a natural extract from the pineal gland. Its key characteristics include:

Purported anti-aging properties
Potential to stimulate production of telomerase (an enzyme that can help maintain telomere length)
Possible regulation of melatonin production and circadian rhythms
Studies suggesting effects on immune function

Most research on Epithalon has been conducted in Russia, with some animal studies showing potential lifespan extension effects.

Telomere Dynamics and Telomerase Activity

Longevity and Anti-Aging Effects

Epithalon influences gene expression related to aging and stress responses, potentially through interactions with DNA⁹.

Antioxidant Properties

Tumor Inhibition

The antitumor effects of Epithalon are partly attributed to its ability to downregulate oncogene expression, such as HER-2/neu in mammary tumors¹¹.

References

Khavinson, V., Bondarev, I., & Butyugov, A. (2003). Epithalon Peptide Induces Telomerase Activity and Telomere Elongation in Human Somatic Cells. Bulletin of Experimental Biology and Medicine, 135, 590-592. https://doi.org/10.1023/A:1025493705728.
Shi-Liang, T. (2007). Retarding the cellular senescence by Epithalon and changes of telomere length and telomerase activity in the retarding process. Journal of Chongqing College of Education.
Anisimov, V., Khavinson, V., Popovich, I., Zabezhinski, M., Alimova, I., Rosenfeld, S., Zavarzina, N., Semenchenko, A., & Yashin, A. (2004). Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology, 4, 193-202. https://doi.org/10.1023/A:1025114230714.
Khavinson, V., Izmaylov, D., Obukhova, L., & Malinin, V. (2000). Effect of epitalon on the lifespan increase in Drosophila melanogaster . Mechanisms of Ageing and Development, 120, 141-149. https://doi.org/10.1016/S0047-6374(00)00217-7.
Khavinson, V., Bondarev, I., Butyugov, A., & Smirnova, T. (2004). Peptide Promotes Overcoming of the Division Limit in Human Somatic Cell. Bulletin of Experimental Biology and Medicine, 137, 503-506. https://doi.org/10.1023/B:BEBM.0000038164.49947.8c.
Rosenfeld, S., Togo, E., Mikheev, V., Popovich, I., Zabezhinskii, M., Khavinson, V., & Anisimov, V. (2002). Effect of Epithalon on the Incidence of Chromosome Aberrations in Senescence-Accelerated Mice. Bulletin of Experimental Biology and Medicine, 133, 274-276. https://doi.org/10.1023/A:1015899003974.
Yue, X., Liu, S., Guo, J., Meng, T., Zhang, X., Li, H., Song, C., Wang, Z., Schatten, H., Sun, Q., & Guo, X. (2022). Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro. Aging (Albany NY), 14, 3191 – 3202. https://doi.org/10.18632/aging.204007.
Goncharova, N., Vengerin, A., Khavinson, V., & Lapin, B. (2005). Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas. Experimental Gerontology, 40, 51-57. https://doi.org/10.1016/j.exger.2004.10.004.
Khavinson, V., & Malinin, V. (2005). Gerontological Aspects of Genome Peptide Regulation. . https://doi.org/10.1159/isbn.978-3-318-01193-7.
Kozina, L., Arutjunyan, A., & Khavinson, V. (2007). Antioxidant properties of geroprotective peptides of the pineal gland.. Archives of gerontology and geriatrics, 44 Suppl 1, 213-6 . https://doi.org/10.1016/J.ARCHGER.2007.01.029.
Anisimov, V., Khavinsov, V., Alimova, I., Provintsiali, M., Manchini, R., & Francheski, K. (2002). Epithalon Inhibits Tumor Growth and Expression of HER-2/neu Oncogene in Breast Tumors in Transgenic Mice Characterized by Accelerated Aging. Bulletin of Experimental Biology and Medicine, 133, 167-170. https://doi.org/10.1023/A:1015555023692.
Anisimov, V., Khavinson, V., Popovich, I., & Zabezhinski, M. (2002). Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.. Cancer letters, 183 1, 1-8 . https://doi.org/10.1016/S0304-3835(02)00090-3.

Peptide Information

Property	Value
Peptide Sequence	Ala-Glu-Asp-Gly
Molecular Formula	C14H22N4O9
Molecular Weight	390.35 g/mol
CAS Number	307297-39-8
PubChem CID	219042
Synonyms	307297-39-8, Glycine, L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-, Ala-Glu-Asp-Gly

Epithalon Peptide Structure

Source: PubChem

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