BioIgnite x 90 Vegetable Capsules X
Regular price
Rs. 44,014
- Unit price
- per
100% Authentic
Made in USA
Authorised distributor
1-5 Days delivery
BioIgnite x 90 Vegetable Capsules
Regular price
Rs. 44,014
- Unit price
- per
Price includes all duties and taxes
SKU: SUPP-BIOIGN
FMI's Choice
BioIgnite - Integrated Metabolic Activation Research Formula
BioIgnite is a multi-component research formulation combining a thermogenic amino acid (L-Theanine), a neurostimulant alkaloid (Caffeine), an inflammation-modulating kinase inhibitor (Amlexanox), and a selective β₂-adrenergic agonist (Albuterol). Together, these agents provide a synergistic platform for investigating thermogenesis, glucose metabolism, inflammation, and mitochondrial energy regulation.
Mechanistic Claims
- L-Theanine (150 mg)
- Activates AMPK, inducing browning of white adipose tissue.
- Improves glucose tolerance and insulin sensitivity.
- Enhances mitochondrial fatty acid oxidation.
- Caffeine (50 mg)
- Adenosine receptor antagonist; increases cAMP signaling.
- Stimulates lipolysis, fat oxidation, and resting energy expenditure.
- Mobilizes free fatty acids for metabolic use.
- Amlexanox (50 mg)
- Inhibits IKK-ε/TBK1, reducing metabolic inflammation.
- Restores catecholamine responsiveness in adipocytes.
- Improves glycemia and reduces fatty liver pathology in preclinical models.
- Albuterol (3 mg)
- Selective β₂-adrenergic agonist.
- Activates human brown adipose tissue, increasing energy expenditure.
- Enhances muscle glucose uptake and fat oxidation.
Research Applications
- Thermogenesis & Fat Oxidation: AMPK activation, β₂-adrenergic stimulation, and cAMP-driven lipolysis.
- Glucose Disposal & Insulin Sensitivity: Adipose browning, kinase inhibition, and enhanced muscle uptake.
- Anti-inflammatory Metabolic Support: Targeting IKK-ε/TBK1 pathways to reduce metabolic inflammation.
- Mitochondrial & Energy Metabolism: Increased fatty acid oxidation and oxidative tissue activation.
The BioIgnite Advantage
- Multi-pathway activation of metabolic processes.
- Synergistic blend of amino acid, alkaloid, kinase inhibitor, and adrenergic agonist.
- Suitable for advanced research into obesity, type 2 diabetes, fatty liver disease, and metabolic syndrome.
Research Insights
Thermogenesis & Fat Oxidation
L-Theanine activates AMPK and upregulates UCP1 and PRDM16, promoting browning of white adipose tissue and increasing adaptive thermogenesis in obese mice [1][2]. Caffeine increases 24-hour energy expenditure by ~100 kcal when consumed in multiple doses (~600 mg total) [10][11], mediated by enhanced lipolysis and BAT activation [12]. Albuterol (salbutamol) directly stimulates β₂ receptors in human brown fat, acutely raising resting metabolic rate and lipid utilization [6][7]. In rats, the combination of albuterol with caffeine produced significantly greater lean mass gain and fat loss compared to either agent alone [6].
Glucose Disposal & Insulin Sensitivity
L-Theanine supplementation improved glucose tolerance and insulin sensitivity in diet-induced obese mice, lowering plasma triglycerides and cholesterol [2][3]. Amlexanox increased insulin sensitivity in obese mice [4] and improved HbA1c in a subset of type 2 diabetic patients, particularly those with inflammatory adipose signatures [5]. Albuterol enhances glucose uptake in skeletal muscle and BAT during β₂ activation, supporting systemic glucose clearance [6][7].
Anti-inflammatory Metabolic Support
Amlexanox inhibits obesity-induced IKK-ε/TBK1 signaling, a pathway that normally suppresses energy expenditure and promotes adipose inflammation [4]. By blocking this brake, amlexanox restores catecholamine responsiveness in adipocytes, increases FGF21 secretion, and improves fatty liver disease [5]. L-Theanine also exerts antioxidant and anti-inflammatory actions in liver and fat tissue, supporting better insulin receptor signaling [3].
Mitochondrial & Energy Metabolism
Caffeine preserves mitochondrial function by upregulating biogenesis pathways via AMPK and catecholamine signaling [10][12]. L-Theanine enhances oxidative metabolism through AMPK–α-ketoglutarate coupling [1]. Albuterol increases mitochondrial uncoupling in BAT and enhances fat oxidation in skeletal muscle [6][7]. Together, these effects foster efficient fuel utilization and higher metabolic rate.
References
- Front Endocrinol. 2024 – L-Theanine activates AMPK, drives adipose browning via PRDM16 demethylation. https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1458848/pdf
- Peng et al. Diabetes. 2021 – L-Theanine increases adaptive thermogenesis & improves insulin sensitivity in obese mice. https://pubmed.ncbi.nlm.nih.gov/33863801/
- Front Nutr. 2022 – L-Theanine intake linked with reduced diabetes risk and improved glucose handling. https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.853846/full
- Reilly et al. Nat Med. 2013 – Amlexanox inhibits IKK-ε/TBK1, reverses obesity-induced inflammation, increases energy expenditure. https://pubmed.ncbi.nlm.nih.gov/23396211/
- Oral et al. Cell Metab. 2017 – Amlexanox improves HbA1c and fatty liver in inflammatory type 2 diabetes subset. https://www.lsi.umich.edu/news/2017-07/repurposed-asthma-drug-shows-blood-sugar-improvement-among-some-diabetics
- Schreiber et al. Obesity. 2015 – Albuterol + caffeine combo increases lean mass, reduces fat mass in rats. https://pmc.ncbi.nlm.nih.gov/articles/PMC4551658/
- Straat et al. Cell Rep Med. 2023 – Salbutamol activates human brown adipose tissue and increases whole-body energy expenditure. https://www.researchgate.net/publication/368698239_Stimulation_of_the_beta-2-adrenergic_receptor_with_salbutamol_activates_human_brown_adipose_tissue
- PubMed 33863801 – AMPK activation required for L-Theanine-induced WAT browning. https://pubmed.ncbi.nlm.nih.gov/33863801/
- LSI Michigan 2017 – Repurposed asthma drug (amlexanox) improves blood sugar and fatty liver in humans. https://www.lsi.umich.edu/news/2017-07/repurposed-asthma-drug-shows-blood-sugar-improvement-among-some-diabetics
- Front Physiol. 2021 – Caffeine increases energy expenditure and fat oxidation in humans. https://pmc.ncbi.nlm.nih.gov/articles/PMC7889509/
-
Astrup et al. 1990 – Caffeine raises 24h energy expenditure in humans. https://pmc.ncbi.nlm.nih.gov/articles/PMC7889509/
- Murphy et al. 2017 – Caffeine antagonism of adenosine receptors activates orexin neurons, driving BAT thermogenesis. https://pmc.ncbi.nlm.nih.gov/articles/PMC7889509/
Label--
| Supplement Facts Serving Size: 1 Capsule Servings per Container: 90 |
|
| Ingredients | Amount Per Serving |
| L-Theanine | 150 mg |
| Caffeine | 50 mg |
| Amlexanox | 50 mg |
| Albuterol | 3 mg |
Dosage--For Research Purposes Only
This content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions about specific peptides and their researched benefits, is presented for informational purposes only and must not be construed as health, clinical, or legal guidance, nor an encouragement for non-research use in humans. Peptides described here are solely for use in structured scientific study by authorized individuals. We advise consulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining or utilizing these peptides. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research peptides.
Store in a dry and dark place at room temperature, out of reach of small children.
Additional Taxes may apply for shipping to GCC
100% Authentic
Made in USA
Authorised distributor
3 - 10 days delivery
Click to read - How we deliver to India
Disclaimer
Product Information Sheet
: Not a diet substitute. Seek Medical guidance if unsure before use.
BioIgnite - Integrated Metabolic Activation Research Formula
BioIgnite is a multi-component research formulation combining a thermogenic amino acid (L-Theanine), a neurostimulant alkaloid (Caffeine), an inflammation-modulating kinase inhibitor (Amlexanox), and a selective β₂-adrenergic agonist (Albuterol). Together, these agents provide a synergistic platform for investigating thermogenesis, glucose metabolism, inflammation, and mitochondrial energy regulation.
Mechanistic Claims
- L-Theanine (150 mg)
- Activates AMPK, inducing browning of white adipose tissue.
- Improves glucose tolerance and insulin sensitivity.
- Enhances mitochondrial fatty acid oxidation.
- Caffeine (50 mg)
- Adenosine receptor antagonist; increases cAMP signaling.
- Stimulates lipolysis, fat oxidation, and resting energy expenditure.
- Mobilizes free fatty acids for metabolic use.
- Amlexanox (50 mg)
- Inhibits IKK-ε/TBK1, reducing metabolic inflammation.
- Restores catecholamine responsiveness in adipocytes.
- Improves glycemia and reduces fatty liver pathology in preclinical models.
- Albuterol (3 mg)
- Selective β₂-adrenergic agonist.
- Activates human brown adipose tissue, increasing energy expenditure.
- Enhances muscle glucose uptake and fat oxidation.
Research Applications
- Thermogenesis & Fat Oxidation: AMPK activation, β₂-adrenergic stimulation, and cAMP-driven lipolysis.
- Glucose Disposal & Insulin Sensitivity: Adipose browning, kinase inhibition, and enhanced muscle uptake.
- Anti-inflammatory Metabolic Support: Targeting IKK-ε/TBK1 pathways to reduce metabolic inflammation.
- Mitochondrial & Energy Metabolism: Increased fatty acid oxidation and oxidative tissue activation.
The BioIgnite Advantage
- Multi-pathway activation of metabolic processes.
- Synergistic blend of amino acid, alkaloid, kinase inhibitor, and adrenergic agonist.
- Suitable for advanced research into obesity, type 2 diabetes, fatty liver disease, and metabolic syndrome.
Research Insights
Thermogenesis & Fat Oxidation
L-Theanine activates AMPK and upregulates UCP1 and PRDM16, promoting browning of white adipose tissue and increasing adaptive thermogenesis in obese mice [1][2]. Caffeine increases 24-hour energy expenditure by ~100 kcal when consumed in multiple doses (~600 mg total) [10][11], mediated by enhanced lipolysis and BAT activation [12]. Albuterol (salbutamol) directly stimulates β₂ receptors in human brown fat, acutely raising resting metabolic rate and lipid utilization [6][7]. In rats, the combination of albuterol with caffeine produced significantly greater lean mass gain and fat loss compared to either agent alone [6].
Glucose Disposal & Insulin Sensitivity
L-Theanine supplementation improved glucose tolerance and insulin sensitivity in diet-induced obese mice, lowering plasma triglycerides and cholesterol [2][3]. Amlexanox increased insulin sensitivity in obese mice [4] and improved HbA1c in a subset of type 2 diabetic patients, particularly those with inflammatory adipose signatures [5]. Albuterol enhances glucose uptake in skeletal muscle and BAT during β₂ activation, supporting systemic glucose clearance [6][7].
Anti-inflammatory Metabolic Support
Amlexanox inhibits obesity-induced IKK-ε/TBK1 signaling, a pathway that normally suppresses energy expenditure and promotes adipose inflammation [4]. By blocking this brake, amlexanox restores catecholamine responsiveness in adipocytes, increases FGF21 secretion, and improves fatty liver disease [5]. L-Theanine also exerts antioxidant and anti-inflammatory actions in liver and fat tissue, supporting better insulin receptor signaling [3].
Mitochondrial & Energy Metabolism
Caffeine preserves mitochondrial function by upregulating biogenesis pathways via AMPK and catecholamine signaling [10][12]. L-Theanine enhances oxidative metabolism through AMPK–α-ketoglutarate coupling [1]. Albuterol increases mitochondrial uncoupling in BAT and enhances fat oxidation in skeletal muscle [6][7]. Together, these effects foster efficient fuel utilization and higher metabolic rate.
References
- Front Endocrinol. 2024 – L-Theanine activates AMPK, drives adipose browning via PRDM16 demethylation. https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2024.1458848/pdf
- Peng et al. Diabetes. 2021 – L-Theanine increases adaptive thermogenesis & improves insulin sensitivity in obese mice. https://pubmed.ncbi.nlm.nih.gov/33863801/
- Front Nutr. 2022 – L-Theanine intake linked with reduced diabetes risk and improved glucose handling. https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.853846/full
- Reilly et al. Nat Med. 2013 – Amlexanox inhibits IKK-ε/TBK1, reverses obesity-induced inflammation, increases energy expenditure. https://pubmed.ncbi.nlm.nih.gov/23396211/
- Oral et al. Cell Metab. 2017 – Amlexanox improves HbA1c and fatty liver in inflammatory type 2 diabetes subset. https://www.lsi.umich.edu/news/2017-07/repurposed-asthma-drug-shows-blood-sugar-improvement-among-some-diabetics
- Schreiber et al. Obesity. 2015 – Albuterol + caffeine combo increases lean mass, reduces fat mass in rats. https://pmc.ncbi.nlm.nih.gov/articles/PMC4551658/
- Straat et al. Cell Rep Med. 2023 – Salbutamol activates human brown adipose tissue and increases whole-body energy expenditure. https://www.researchgate.net/publication/368698239_Stimulation_of_the_beta-2-adrenergic_receptor_with_salbutamol_activates_human_brown_adipose_tissue
- PubMed 33863801 – AMPK activation required for L-Theanine-induced WAT browning. https://pubmed.ncbi.nlm.nih.gov/33863801/
- LSI Michigan 2017 – Repurposed asthma drug (amlexanox) improves blood sugar and fatty liver in humans. https://www.lsi.umich.edu/news/2017-07/repurposed-asthma-drug-shows-blood-sugar-improvement-among-some-diabetics
- Front Physiol. 2021 – Caffeine increases energy expenditure and fat oxidation in humans. https://pmc.ncbi.nlm.nih.gov/articles/PMC7889509/
-
Astrup et al. 1990 – Caffeine raises 24h energy expenditure in humans. https://pmc.ncbi.nlm.nih.gov/articles/PMC7889509/
- Murphy et al. 2017 – Caffeine antagonism of adenosine receptors activates orexin neurons, driving BAT thermogenesis. https://pmc.ncbi.nlm.nih.gov/articles/PMC7889509/
| Supplement Facts Serving Size: 1 Capsule Servings per Container: 90 |
|
| Ingredients | Amount Per Serving |
| L-Theanine | 150 mg |
| Caffeine | 50 mg |
| Amlexanox | 50 mg |
| Albuterol | 3 mg |
For Research Purposes Only
This content is provided strictly for research purposes and does not constitute an endorsement or recommendation for the non-laboratory application or improper handling of peptides designed for research. The information, including discussions about specific peptides and their researched benefits, is presented for informational purposes only and must not be construed as health, clinical, or legal guidance, nor an encouragement for non-research use in humans. Peptides described here are solely for use in structured scientific study by authorized individuals. We advise consulting with research experts, medical practitioners, or legal counsel prior to any decisions about obtaining or utilizing these peptides. The expectation of responsible, ethical utilization of this information for legitimate investigative and scholarly objectives is paramount. This notice is dynamic and governs all provided content on research peptides.
Store in a dry and dark place at room temperature, out of reach of small children.
